PLATLET AND COAGULATION DISORDERS
DISORDER
EXPLANATION
HEMOPHILIA
Hemophilia is one of a group of inherited bleeding disorders that
cause abnormal or exaggerated bleeding and poor blood
clotting because it lacks sufficient blood-clotting proteins
(clotting factors). Hemophilia A and B are inherited in an X-
linked recessive genetic pattern, so males are commonly affected
while females are usually carriers of the disease.
VON WILLEBRAND
DISEASE
It is a genetic disorder caused by missing or defective von
Willebrandfactor (VWF), a clotting protein. VWF binds factor
VIII, a key clotting protein, and platelets in blood vessel walls,
which help form a platelet plug during the clotting process.
DEFICIENCY OF
VITAMIN K
A lack of vitamin K resulting in an increase in the clotting time of
the blood as vitamin K helps in activation of clotting factors,
impaired clotting leads to excessive bleeding.
BERNAR-SOULIER
SYNDROME
It is also called hemorrhagiparous thrombocytic dystrophy, is a
rare autosomal recessive bleedingdisorder that causes a
deficiency of glycoprotein Ib (GpIb), the receptor for von
PLATELET DISORDER
• Deficiency of Vitamin K
• Bernar-Soulier Syndrome
• Gray Platelet Syndrome
• Dense Granule Deficiency
Syndrome
• Thrombotic
Thrombocytopenic Purpura
• Idiopathic
Thrombocytopenic Purpura
COAGULATION DISORDER
• Hemophilia
• Von Willebrand Disease
Willebrand factor.
GRAY PLATELET
SYNDROME
It is a rare congenital autosomal recessive
bleeding disorder caused by a reduction or absence of alpha-
granules in blood platelets, and the release of proteins normally
contained in these granules into the marrow, causing
myelofibrosis.
THROMBOTIC
THROMBOCYTOPENIC
PURPURA
It is a rare disorder of the blood-coagulation system, causing
extensive microscopic clots to form in the small blood vessels
throughout the body, resulting in low platelet counts.
IDIOPATHIC
THROMBOCYTOPENIC
PURPURA
It is a bleeding disorder in which the immunesystem destroys
platelets, which results in excessive bleeding.
